EurekAlert!·3 min read·hard
Xbp1s-Stat3 axis drives pathological cardiac fibrosis in mice
✦AI Summary
Researchers have identified the Xbp1s-Stat3 axis as a key driver in the development of pathological cardiac fibrosis in mice. This biological mechanism involves the transformation of cardiac fibroblasts into myofibroblasts, which contributes to chronic heart failure.
Why it matters
Understanding this molecular pathway could lead to new therapeutic targets for treating chronic heart failure in humans.
Pathological cardiac fibrosis is a central hallmark of chronic heart failure, characterized by the maladaptive transformation…
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