MIT Technology Review·4 min read·medium

We’re still figuring out the side effects of GLP-1 weight-loss drugs

J
Jessica Hamzelou
We’re still figuring out the side effects of GLP-1 weight-loss drugs
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This piece examines the emerging side effects and potential longevity benefits of GLP-1 weight-loss drugs like Ozempic and Wegovy. It notes that while these drugs are highly effective, researchers are still uncovering the full scope of their long-term health impacts.

Why it matters

With millions of people using GLP-1 agonists, understanding the full spectrum of side effects is essential for public health and patient safety.

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Could the drugs affect hair, nails, and vision?

This week my colleague Antonio Regalado had an interesting update on GLP-1 weight-loss drugs. According to research presented at an aging meeting in Boston, these drugs seem to affect at least some measures of biological age .

Overweight and diabetic people who take GLP-1s have a biological age around two to three years younger than similar individuals who take a placebo, according to findings from Eli Lilly and Novo Nordisk, two pharmaceutical companies that make the drugs.

I’ve heard people in the aging field describe GLP-1s as longevity drugs for a while now (even if they only benefit people who are overweight or diabetic in the first place). This latest announcement comes after we’ve seen a raft of other benefits associated with taking these drugs. But there are also some weird side effects.

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