Uterus Transplants Aid Women in Successful Pregnancies

PHILADELPHIA - A decade of uterus transplantation in the United States has resulted in dozens of healthy births and steadily improving surgical outcomes, according to a new national review led by researchers from the Perelman School of Medicine at the University of Pennsylvania . The study found that 70 percent of uterus transplant recipients achieved at least one live birth (or were still pregnant beyond 20 weeks when the study closed), demonstrating that the procedure has matured from an experimental intervention into a replicable clinical therapy for women born without a uterus or those whose uteruses cannot support pregnancy.

The findings, published in Obstetrics & Gynecology, [EH1] summarize outcomes from 60 uterus transplants performed between 2016 and 2025 at the four U.S. centers that have offered the procedure. The analysis represents nearly the entire U.S. experience with uterus transplantation and includes surgical, reproductive, neonatal, and early childhood developmental outcomes.