Transcription factor ELF-1 drives inflammatory macrophage to exacerbate AKI by GBP4/NLRs/NF-κB axis
A study published in Communications Biology identifies the transcription factor ELF-1 as a key driver of inflammatory M1 macrophage polarization in post-transplant acute kidney injury. The research demonstrates that ELF-1 deficiency can attenuate kidney injury, suggesting a potential therapeutic target.
Why it matters
This research provides a potential pathway for improving outcomes in renal transplantation by mitigating inflammatory responses.
Communications Biology ( 2026 ) Cite this article
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.
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