Too much RNA can starve cells of energy, scientists discover
Scientists have discovered that an excess of RNA inside cells can damage mitochondria and starve cells of energy. The research highlights a vital role for RNA degradation in maintaining cellular energy supplies, which could impact understanding of aging and RNA-based medical treatments.
Why it matters
Understanding how RNA buildup affects cellular energy could improve the safety and efficacy of modern therapeutics like mRNA vaccines and shed light on aging-related diseases.
Scientists have uncovered a surprising way that viruses can interfere with the body's cells. When too much RNA accumulates inside a cell, it can damage the structures that produce energy, potentially leaving the cell struggling to function normally.
A new study led by researchers at the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) found that excess RNA produced during poxvirus infections can impair mitochondria, the tiny structures responsible for generating most of the energy cells need to survive.
Published in Proceedings of the National Academy of Sciences , the research reveals an unexpected connection between RNA buildup and cellular energy production. The findings could have implications far beyond viral infections, potentially helping scientists better understand aging-related diseases and improve RNA-based medical treatments, including mRNA vaccines.
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