The same immune cells play opposing roles in tissue regeneration's balancing act
Researchers at the Jackson Laboratory have discovered that specific T cells play a dual role in tissue regeneration, both hindering and protecting bone-making cells. This finding suggests that the body's regenerative potential may be greater than previously understood.
Why it matters
Understanding these immune mechanisms could lead to new medical therapies that enhance the body's ability to heal after severe injuries.
by Roberto Molar Candanosa, Jackson Laboratory
edited by Sadie Harley , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add to Preferred Sources While T cells help protect the body against cancer and viruses, new research shows that some T cells can also limit the body's ability to regenerate tissue. Here, CD4 + T cells (green) kill progenitor cells, which help drive tissue regeneration. As the progenitor cells die, they appear magenta. Credit: James Godwin, Ph.D. In a study of fingertip regeneration, a team led by JAX senior research scientist James Godwin found that some immune cells in mice can attack and kill cells needed to rebuild bone, while a subset of those same immune cells can protect the bone-making cells and allow regeneration to continue.
Get smarter about the news
Sign up free for a feed built around what you actually care about, Dive Deeper research on any story, and the full text of every article.
Create free accountAlready have an account? Sign in