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Nature·4 min read·hard

The lncRNA PHAROH augments MYC mRNA levels in insulin-producing cells by counteracting TIA1-induced MYC silencing

Z
Zhao, Tongjian
The lncRNA PHAROH augments MYC mRNA levels in insulin-producing cells by counteracting TIA1-induced MYC silencing
AI Summary

Researchers have identified that the long non-coding RNA PHAROH plays a critical role in regulating MYC mRNA levels in insulin-producing beta cells during stress. By counteracting the inhibitory effects of the protein TIA1, PHAROH helps maintain beta cell function, offering new insights into diabetes pathology.

Why it matters

Understanding the molecular mechanisms of beta cell survival under stress is essential for developing new therapeutic strategies for type 1 and type 2 diabetes.

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Scientific Reports volume 16 , Article number: 25916 ( 2026 ) Cite this article

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