Structural study explains how cells stabilize protective membrane pockets
Researchers at the Max Delbrück Center have identified the protein structure that stabilizes caveolae, the bottle-shaped membrane pockets in human cells. This discovery could lead to new treatments for lipid metabolism disorders by regulating how cells absorb nutrients.
Why it matters
Understanding cellular membrane stabilization provides critical insights into how cells manage mechanical stress and nutrient uptake, potentially unlocking new medical therapies.
by Max Delbrück Center for Molecular Medicine
edited by Gaby Clark , reviewed by Robert Egan
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Add as preferred source Structure determination of membrane-bound EHD2. Credit: Nature Communications (2026). DOI: 10.1038/s41467-026-76288-8 Our cells' membranes have many functions. They not only provide mechanical protection but also precisely control which substances enter or leave cells. If they fail to perform these tasks, disease can result. Their structure is correspondingly complex: The outer cell membrane, for example, often features bottle-shaped invaginations called caveolae. Among other functions, they protect blood vessel cells, which are frequently exposed to strong mechanical forces. In addition, caveolae serve as signaling centers that help regulate blood pressure. Cells also absorb nutrients—especially fatty acids—via caveolae.
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