Some Keto Diets May Trigger Mitochondrial Stress, Inflammation
Research from the University of Cincinnati suggests that ketogenic diets high in long-chain saturated fatty acids may increase inflammation and mitochondrial stress. The study indicates that not all fats are equal, with unsaturated and medium-chain fats potentially offering anti-inflammatory benefits.
Why it matters
This research provides nuanced guidance for individuals using ketogenic diets, suggesting that the specific source of fat is critical to health outcomes.
New University of Cincinnati Cancer Center research found a ketogenic diet high in long-chain saturated fatty acids can increase inflammation.
Led by Cancer Center Director David Gius, MD, PhD, the study was published Nov. 13 in the journal Science Advances.
A ketogenic diet is high in fat and low in carbohydrates, with the goal of entering ketosis, a metabolic state where the body burns fat and ketones for fuel instead of glucose. While many previous studies have demonstrated anti-inflammatory benefits from a ketogenic diet, other studies have shown increased inflammation and other harmful effects. Gius and colleagues have identified a potential factor contributing to these divergent outcomes.
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