Shared signaling regulator may link liver and pancreas dysfunction in type 2 diabetes
Kyoto University researchers identified the protein CA8 as a potential link between liver and pancreas dysfunction in type 2 diabetes. The study suggests that CA8 regulates calcium signaling, which is critical for insulin secretion and glucose production.
Why it matters
Understanding this molecular mechanism could provide new therapeutic targets for managing blood glucose levels in diabetic patients.
edited by Sadie Harley , reviewed by Robert Egan
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Add to Preferred Sources The role of CA8 in glucose homeostasis and T2D pathogenesis. Credit: Science Advances (2026). https://www.science.org/doi/10.1126/sciadv.aeh4948 Maintaining healthy blood glucose levels involves striking a balance between the glucose produced by the liver during fasting and the insulin released from pancreatic beta cells after meals. In type 2 diabetes, glucose production goes into overdrive while insulin secretion becomes insufficient, a multiorgan dysfunction that contributes to hyperglycemia, or high blood glucose levels.
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