Scripps Research chemists crack stereoretention challenge in radical cross-coupling
Chemists at Scripps Research have developed a new nickel-catalyzed cross-coupling reaction that maintains 3D molecular geometry during synthesis. This method simplifies the production of complex pharmaceutical building blocks without requiring chiral ligands.
Why it matters
This breakthrough could significantly reduce waste and shorten synthetic routes in drug discovery, lowering costs for pharmaceutical manufacturing.
The radical rebound. Computational visualisation showing the carbon-centred radical (orange spin density) binding to the nickel-centred radical (blue spin density). Two perspectives are shown.
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