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Wired·4 min read·hard

Scientists Used AI to Create 16 New Viruses

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Fernanda González
Scientists Used AI to Create 16 New Viruses
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Scientists from Stanford and the Arc Institute have used AI models to design 16 entirely new, functional bacteriophages. These synthetic viruses, created by analyzing millions of natural genetic sequences, offer potential as alternatives to antibiotics for treating resistant bacterial infections.

Why it matters

This breakthrough represents a significant advancement in synthetic biology and AI-driven drug discovery, potentially revolutionizing how we combat antibiotic-resistant bacteria.

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For several years now, scientists have been able to synthesize viruses from scratch; these are typically used to develop and evaluate antiviral drugs and vaccines, as well as to expand our understanding of how these microorganisms behave. However, the production of these viral genomes has primarily relied on replicating previously known pathogens or variants.

In contrast, a new study conducted by scientists at Stanford University and the Arc Institute succeeded in having an AI design simple, functional, and previously unseen viruses based on information contained in the genetic sequences of millions of animals, plants, microbes, bacteria, and viruses found in nature

The researchers worked with bacteriophages—microorganisms characterized by relatively small genomes, which are relatively easy to synthesize and manipulate under controlled conditions. These viruses infect only bacteria, making them a tool with enormous biotechnological potential and a promising alternative to antibiotics for combating resistant bacterial infections.

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