Scientists say creatine may help fight depression

A systematic review of existing clinical trials suggests that creatine supplements may help alleviate symptoms of depression by supporting brain energy needs. However, results remain inconsistent across different studies, requiring further research.
Why it matters
If proven effective, creatine could offer a low-cost, accessible, and safe adjunct treatment for major depressive disorder.
Creatine is one of the world's most popular sports supplements, widely used to improve strength and muscle performance. Now, researchers are exploring whether it could have benefits far beyond the gym. A new systematic review published in Brain Medicine examined whether creatine might help relieve depression by supporting the brain's energy needs.
The article presents a balanced view of scientific findings, acknowledging both potential benefits and current limitations.
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