Scientists restore lost protein to reverse lung disease in preclinical models

edited by Gaby Clark , reviewed by Andrew Zinin

This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:

Add as preferred source Yassine Sassi (standing), associate professor at the Fralin Biomedical Research Institute at VTC, and Aymen Halouani, first author of the study, identified BMP3 as a promising new therapeutic target for pulmonary arterial hypertension. Their team's findings, published in the European Respiratory Journal, showed that restoring the protein reversed key features of the disease in preclinical models. Credit: Clayton Metz/Virginia Tech Researchers at the Fralin Biomedical Research Institute at VTC have identified a natural protective protein that maintains healthy lung blood vessels. Increasing the expression of this protein in preclinical models of pulmonary arterial hypertension reversed key features of the disease, including pulmonary vascular remodeling and heart dysfunction.