Scientists find how “zombie” cells fuel inflammation as we age
Researchers have uncovered a previously unknown connection between senescent 'zombie' cells, mitochondria, and cell metabolism, explaining how these cells fuel chronic inflammation associated with aging. Interfering with this process was shown to reduce inflammation and support healthier aging in mice. This discovery could lead to new strategies for combating age-related diseases.
Why it matters
Chronic inflammation is linked to numerous age-related diseases; understanding its cellular mechanisms could lead to new therapeutic interventions to promote healthier aging and treat these conditions.
Inflammation is one of the immune system's most important defenses. When the body detects an infection or injury, it sends out alarm signals that recruit immune cells and other cells to eliminate the threat and begin repairing damaged tissue.
This response is essential, but it is supposed to shut down once the danger has passed. As people age, however, certain cells accumulate that can keep inflammation active for much longer than necessary. This persistent inflammation has been associated with numerous diseases that become more common later in life.
Researchers at Sanford Burnham Prebys Medical Discovery Institute, Mayo Clinic, and collaborating institutions have now uncovered a previously unknown connection between mitochondria, cell metabolism, and this chronic inflammation. Their findings, published in Nature , also showed that interfering with part of the process reduced inflammation and supported healthier aging in mice.
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