Scientists finally uncover why statins can cause muscle pain
Researchers have identified a molecular mechanism explaining why statins can cause muscle pain, discovering that the drugs can cause a harmful calcium leak in muscle cells. This discovery could lead to the development of safer cholesterol-lowering medications.
Why it matters
Understanding this side effect is crucial for improving patient adherence to life-saving cardiovascular treatments.
Statins are among the most important medications for preventing cardiovascular disease. By lowering cholesterol, they have helped save millions of lives and reduce the likelihood of heart attacks and strokes. However, these benefits can come with unwanted effects. Some patients develop muscle pain or weakness, while a small number experience serious muscle breakdown that can potentially cause kidney failure.
Scientists at the University of British Columbia (UBC), working with colleagues at the University of Wisconsin-Madison, have identified a molecular mechanism that helps explain these complications. Their findings, published in Nature Communications , could guide the development of safer statins that maintain their cholesterol-lowering benefits while minimizing muscle damage.
How Statins Trigger a Harmful Calcium Leak
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