SATB1 lowers the T cell receptor signaling threshold for thymocyte positive selection via super-enhancer reprogramming
Researchers have discovered that the protein SATB1 is essential for T cell development by regulating super-enhancer structures. This process helps thymocytes translate weak signals into specific genetic programs during positive selection.
Why it matters
Understanding T cell development is critical for advancing immunology and developing treatments for immune-related disorders.
Nature Communications ( 2026 ) Cite this article
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.
Get smarter about the news
Sign up free for a feed built around what you actually care about, Dive Deeper research on any story, and the full text of every article.
Create free accountAlready have an account? Sign in