Rotenone targeting the oxidative phosphorylation pathway improves invasive lesions in ovarian endometriosis

Researchers have identified that the oxidative phosphorylation (OXPHOS) pathway is involved in the progression of ovarian endometriosis. The study suggests that the drug Rotenone can suppress the growth and migration of endometrial cells in laboratory and animal models.
Why it matters
This research offers a potential new therapeutic target for treating endometriosis, a condition that currently lacks effective long-term medical solutions.
Scientific Reports ( 2026 ) Cite this article
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.
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