Researchers estimate the upper limit of human lifespan determined by somatic mutations
Researchers have developed a mathematical model to determine how somatic mutations limit the human lifespan. The study suggests that while some tissues can regenerate indefinitely, non-dividing cells like neurons act as the primary biological constraints on longevity.
Why it matters
Understanding the fundamental biological limits of human life helps clarify the mechanisms of aging and could inform future medical interventions for age-related diseases.
by Oleg Sherbakov, Skolkovo Institute of Science and Technology
edited by Sadie Harley , reviewed by Andrew Zinin
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Add as preferred source Credit: Pixabay/CC0 Public Domain Researchers from Skoltech and co-authors from AIRI have, for the first time, quantitatively assessed how somatic mutations—random DNA changes that accumulate in cells with age—limit the maximum human lifespan. The work was published in the journal npj Aging .
Somatic mutations are random changes in DNA that occur in the body's cells throughout life. Unlike germline mutations, they are not inherited, but they gradually accumulate with age and can damage cells, impair their function and contribute to the development of age-related diseases.
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