Raman imaging applied to cardiac tissue of Fabry disease model reveals molecular map of lipids in tissue
Researchers have developed a new imaging technique that combines Raman microscopy and mass spectrometry to create high-resolution molecular maps of tissue. This method was successfully tested on heart tissue from a Fabry disease mouse model to visualize lipid accumulation.
Why it matters
This analytical breakthrough allows for more precise early diagnosis and targeted treatment strategies for rare metabolic and genetic diseases.
by Sara Rebein, Leibniz Institute for Analytical Sciences
edited by Sadie Harley , reviewed by Andrew Zinin
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add as preferred source Graphical abstract. Credit: Analytical Chemistry (2026). DOI: 10.1021/acs.analchem.5c07622 How are disease-relevant molecules distributed within tissue? What changes occur even before they become visible under the microscope? Questions such as these are crucial for early diagnosis and targeted treatment in many diseases. Researchers at the Leibniz-Institut für Analytische Wissenschaften—ISAS have, for the first time, succeeded in combining two complementary analytical methods to create a high-resolution molecular map of tissue. Their map makes different biomolecules simultaneously visible and reveals their spatial distribution.
The researchers have now published their development and its application, using Fabry disease as a case study, in the journal Analytical Chemistry .
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