Prolonged stretching reorganizes tissue scaffolds and uncages cell nuclei
Researchers at the Institute for Bioengineering of Catalonia have discovered that prolonged tissue stretching causes cells to reorganize their internal keratin scaffolding. This process creates star-shaped bundles that exert force, eventually pushing the cell nucleus out of its protective cage.
Why it matters
Understanding how cells adapt to mechanical stress provides critical insights into tissue development, disease progression, and potential regenerative medicine applications.
by Institute for Bioengineering of Catalonia
edited by Sadie Harley , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add as preferred source Credit: Institute for Bioengineering of Catalonia (IBEC) How do tissues cope with being stretched for hours or even days? A study led by researchers at the Institute for Bioengineering of Catalonia (IBEC) has uncovered an unexpected answer: Cells radically reorganize their internal scaffolding and, in the process, release their nuclei from a protective keratin network.
The work, published in Nature Physics , reveals a new way in which tissues adapt to long-lasting mechanical forces.
Get smarter about the news
Sign up free for a feed built around what you actually care about, Dive Deeper research on any story, and the full text of every article.
Create free accountAlready have an account? Sign in