PRKACA modulates endoplasmic reticulum stress-associated dysfunction in granulosa cell models relevant to polycystic ovary syndrome

Researchers have identified the PRKACA gene as a key modulator of endoplasmic reticulum stress in granulosa cells, which are linked to polycystic ovary syndrome (PCOS). Functional studies indicate that PRKACA helps maintain cellular homeostasis and hormone secretion, offering potential insights into the molecular mechanisms of the condition.