Prisco's Week 1 NFL picks: Rams edge 49ers, Bills end skid vs. Texans
Pete Prisco, a CBS Sports analyst, provides his Week 1 NFL picks, acknowledging the difficulty of predicting early-season outcomes due to unknown team performances and player impacts. He offers specific predictions for several games, including the Seahawks dominating the Patriots, the Rams narrowly beating the 49ers, the Steelers defeating the Falcons, the Ravens winning against the Colts, and the Bills breaking their losing streak against the Texans.
Why it matters
For NFL fans, these predictions offer insights, discussion points, and potential guidance for fantasy football or betting, setting the stage for the start of the new season.
It's NFL picks time again, which means Week 1 torture.
Figuring out Week 1 picks is as complicated as it gets. We have no idea who will be good and who will be bad. How will new coaches impact teams? How will returning injured players show in their first game back?
That makes picking this week's games even tougher than other weeks.
I had a good season in 2025, so let's see if that can carry over this year. The way I see it, if you can navigate the early weeks and settle in for October and November, you have a chance at a good season.
So let's start strong -- even in the face of Week 1 adversity.
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