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Nature·4 min read·hard

Polygenic risk for type 2 diabetes modulates gut microbiome associations across metabolic health traits

J
Jagare, Lauma
Polygenic risk for type 2 diabetes modulates gut microbiome associations across metabolic health traits
✦AI Summary

A study of 821 individuals found that genetic risk for type 2 diabetes interacts with gut microbiome composition to influence metabolic health. While genetics play a role, the study notes that physical activity can mitigate these risks.

Why it matters

Advances personalized medicine by showing how lifestyle choices can potentially override genetic predispositions in metabolic health.

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npj Genomic Medicine ( 2026 ) Cite this article

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.

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