PITX1 safeguards epithelial identity and restrains EMT plasticity
A study identifies the PITX1 transcription factor as a key regulator that maintains epithelial cell identity and suppresses the epithelial-mesenchymal transition (EMT). Loss of this factor is linked to more aggressive, therapy-resistant breast cancer.
Why it matters
Understanding the molecular mechanisms of cancer progression provides potential new targets for therapeutic intervention and prognostic markers for patient survival.
Cell Death & Disease ( 2026 ) Cite this article
We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply.
Get smarter about the news
Sign up free for a feed built around what you actually care about, Dive Deeper research on any story, and the full text of every article.
Create free accountAlready have an account? Sign in