PHLPP1 inhibition in vascular smooth muscle cells alleviates atherosclerotic plaque formation via up-regulating autophagy in ApoE−/− mice
Researchers have discovered that inhibiting the PHLPP1 protein can reduce atherosclerotic plaque formation in mice. The study suggests that this inhibition promotes autophagy in vascular smooth muscle cells via the AMPK signaling pathway.
Why it matters
This finding identifies a potential new therapeutic target for treating atherosclerosis and managing cardiovascular disease risks.
Scientific Reports ( 2026 ) Cite this article
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.
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