Phage and microbiota therapy reduced recurrent UTIs in two patients over two years
A clinical study has demonstrated that a combination of phage therapy and fecal microbiota transplantation can effectively treat recurrent urinary tract infections. The novel approach aims to decolonize bacterial reservoirs in patients who have not responded to standard antibiotics.
Why it matters
As antibiotic resistance grows, this combined therapy offers a promising alternative for treating persistent, drug-resistant bacterial infections.
edited by Swati Mestri , reviewed by Andrew Zinin
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Add as preferred source Treatment overview of PT, antibiotics and FMT. Credit: Nature Microbiology (2026). DOI: 10.1038/s41564-026-02409-0 Recurrent urinary tract infections (rUTIs) are among the most common bacterial infections worldwide and primarily affect women. While antibiotics remain the standard treatment, frequent recurrences and rising antibiotic resistance highlight the need for alternative therapeutic approaches such as phage therapy. Phages are tiny viruses that selectively target bacteria and can effectively destroy even multidrug-resistant bacteria.
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