Pausing Biological Decline

AMID growing concerns over recent HIV outbreak patterns, uncontrolled infection rapidly advances biological aging across proteomes. Leveraging longitudinal data spanning more than 17 years from the Swiss HIV Cohort Study, investigators demonstrated that untreated viremia produces an average of 5.99 years of accelerated biological senescence . The investigation evaluated an independent cohort of 80 individuals with paired plasma samples collected before and during therapy. By establishing a specialized clock utilizing 416 protein abundances, researchers tracked proteomic aging in HIV, demonstrating that premature decay begins reversing promptly once suppressive antiretroviral therapy starts. Significant deceleration was observed within a median of 1.55 years post-initiation, with models projecting convergence toward chronological baseline after roughly 16.4 years.