Pakistan’s Massive Genetic Database Reveals Millions of Unique Variants
The Pakistan Genome Resource has analyzed over 173,000 participants, identifying 6.6 million genetic variants. The study provides new insights into gene functions related to cardiovascular health, obesity, and liver disease.
Why it matters
This massive dataset helps validate drug targets and improves our understanding of human genetic diversity, particularly in underrepresented populations.
The Pakistan Genome Resource (PGR), one of the largest genomic studies ever conducted in South Asia, has revealed novel insights into gene function, disease susceptibility, and the translatability of preclinical findings to humans. Published in a Nature article , a collaboration between Novartis, Columbia University Irving Medical Center, and the Center for Non-Communicable Diseases, Karachi, Pakistan, examined 173,303 PGR participants, constituting 0.07% of the population of Pakistan, the fifth most populous country in the world.
The article reports on scientific findings from a peer-reviewed study without political or social commentary.
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