Optogenetics: Controlling yeast with light
Researchers at the National University of Singapore have developed a method called y-iLight that uses light to control gene activity in yeast. This technology aims to make biomanufacturing more precise and environmentally friendly by eliminating the need for chemical inducers.
Why it matters
Advancements in optogenetics could revolutionize the efficiency and sustainability of producing medicines and fuels through synthetic biology.
NUS College of Design and Engineering PhD student Linus Tan (left), lead author of the study, with Poh Chueh Loo, an associate professor from NUS Synthetic Biology for Clinical and Technological Innovation who led the research.
Listen Summarise NUS researchers developed y-iLight, a red light-responsive protein that controls gene activity in yeast without extra chemicals, making biomanufacturing more reliable and eco-friendly. They combined red and blue light systems to control multiple yeast processes like producing luteolin and triggering cell clumping for cleaner manufacturing. The team created multi-colour yeast patterns using light and aims to improve protein sensitivity and add more light colours for greater control, with plans to commercialise the technology. AI generated
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