NYU Abu Dhabi Study Shows Cells Respond Differently to Cancer Gene
Researchers at NYU Abu Dhabi have identified that cancer-causing genes trigger different types of cellular senescence, which can either suppress or promote tumor growth. The study suggests that current cancer therapies may need to be more targeted, as senolytic drugs do not affect all senescent cells equally.
Why it matters
Understanding the heterogeneity of senescent cells is critical for developing more effective cancer treatments and improving the success rate of senolytic therapies.
Researchers at NYU Abu Dhabi have discovered that a single cancer-causing gene can trigger different responses in cells, with some helping to prevent tumors while others may contribute to their development.
The study, published in EMBO Reports, found that the gene can trigger several forms of cellular senescence, a natural defense in which damaged cells stop dividing to help prevent cancer, a so-called tumor-suppressive function inherent to all cells.
Using a zebrafish model of liver cancer, the researchers investigated the initial response to a cancer-causing gene and found that some of these precancerous cells are terminally senescent, meaning they cannot generate tumors, while others can regain the ability to divide and potentially contribute to cancer.
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