Non-standard proteins in the lens of AlphaFold 3: a case study of amyloids
Researchers evaluated the performance of AlphaFold 3 in predicting the structures of amyloid proteins, finding significant limitations in its accuracy. The study suggests that the model struggles due to a lack of amyloid-specific data in the Protein Data Bank, often misidentifying them as globular proteins.
Why it matters
Improving structural prediction for amyloids is critical for understanding neurodegenerative diseases, as these proteins are often linked to conditions like Alzheimer's.
Scientific Reports ( 2026 ) Cite this article
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