Nitroglycerin May Ease Menopausal Hot Flashes, Study Finds
A new study presented at The Menopause Society meeting suggests that transdermal nitroglycerin may offer a non-hormonal treatment for menopausal hot flashes. While results were mixed, some participants saw a significant reduction in frequency.
Why it matters
Finding effective non-hormonal treatments for menopause symptoms is critical for women who cannot or choose not to use hormone therapy.
CLEVELAND, Ohio (October 20, 2026) - Hot flashes are the most frequent symptom of perimenopause and menopause, affecting 75% to 85% of women. In recent years, there has been a spike in the number of nonhormone options for managing hot flashes. A new study suggests that transdermal nitroglycerin may be an option. Results of the study will be presented at the 2026 Annual Meeting of The Menopause Society in San Diego October 20-24, 2026.
Menopausal hot flashes are not life-threatening, but frequent or severe episodes can significantly disrupt daily life. It is estimated that between 10% and 30% of women have symptoms that are severe enough to impair daily activities, work performance, and overall quality of life. Night sweats can disrupt sleep, leading to chronic fatigue, irritability, and mood changes.
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