NIPT test can predict risk of pregnancy complications in autoimmune disease
Researchers at KU Leuven have developed a computer model that uses NIPT blood samples to predict pregnancy complications in women with autoimmune diseases. The method analyzes DNA fragment patterns to identify risks before symptoms appear, potentially allowing for earlier medical intervention.
Why it matters
This innovation could significantly improve maternal health outcomes by enabling proactive monitoring and treatment for high-risk pregnancies.
NIPT test can predict risk of pregnancy complications in autoimmune disease
Women with conditions such as lupus, rheumatoid arthritis, psoriasis, or Crohn's disease have an increased risk of preterm birth and pre-eclampsia. Until now, clinicians have found it difficult to assess this risk early in pregnancy, as symptoms or abnormal blood values are often not yet present.
The Leuven researchers analysed the so-called fragmentome: the physical characteristics and patterns of free-floating DNA fragments in the blood. Using nearly 2,000 first-trimester blood samples, they developed a computer model that accurately predicts which women will later develop pregnancy complications, even before symptoms appear. The model's results were confirmed in an independent patient group from Ziekenhuis Oost-Limburg.
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