NFL Week 2 odds, predictions: Picks, best bets from 10,000 computer simulations

Even those not on the West Coast could have a little more interest in making Week 2 NFL picks on either the Rams or 49ers. How those teams respond after playing in Australia last week is something that will be highly observed. Both are fortunate to have home games on the Week 2 NFL schedule, with San Fran hosting Miami on Sunday, and L.A. hosting the Giants on Monday. The Niners are 13.5-point favorites for their contest, which is the biggest NFL spread of the young season. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades :