New software helps researchers decode the cellular architecture of lymphoma

by Lisa Vollmar, European Molecular Biology Laboratory

edited by Lisa Lock , reviewed by Robert Egan

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Add as preferred source Multiplexed imaging captures numerous proteins simultaneously in a single tissue sample, such as a lymphoma biopsy, and makes different cell types and tissue structures visible. These can then be analyzed systematically and reproducibly using the "spatialproteomics" software. Credit: UKD How cancer develops and responds to treatment depends not only on the tumor cells themselves but also on the complex ecosystem of surrounding immune cells, blood vessels and connective tissue. In B-cell non-Hodgkin lymphoma, these cellular neighborhoods can determine whether a tumor grows, evades the immune system or responds to therapy. Understanding this spatial organization has become one of the major challenges in cancer research.