New sensing method expands label-free particle detection beyond sensor surfaces

Researchers at Washington University in St. Louis have developed a new sensing method that extends the range of whispering-gallery-mode sensors beyond the immediate surface. This advancement allows for more sensitive detection of rare particles like cancer cells without the need for fluorescent labels.
Why it matters
Improving the sensitivity and range of label-free sensors is crucial for early disease detection and diagnostic efficiency in clinical settings.
by Minerva Pappu, Washington University in St. Louis
edited by Swati Mestri , reviewed by Andrew Zinin
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add to Preferred Sources Lan Yang’s lab unlocked new capabilities for whispering-gallery-mode-based sensors by extending its sensing range beyond the immediate surface, while preserving the exceptional sensitivity that has made these sensors so powerful. This can potentially open entirely new sensing modalities and applications. Credit: Yang lab Finding a single cancer cell in a tube of blood is a bit like finding a needle in a haystack. As researchers seek to detect ever-smaller and rarer targets, from viruses to circulating tumor cells in blood, the demand for ultrasensitive, robust sensors that are practical for real-world samples continues to grow.
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