New research shows the Golgi complex is involved in DNA repair control
Researchers at EMBL Heidelberg have discovered that the Golgi complex, traditionally known for protein sorting, also plays a role in DNA repair. The study identified a network of DNA repair proteins residing at the Golgi, suggesting a new layer of cellular control.
Why it matters
This discovery challenges existing biological models of how cells manage DNA damage, potentially opening new avenues for cancer research.
edited by Lisa Lock , reviewed by Andrew Zinin
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Add as preferred source Fluorescent microscopy image of human cells, with RAD51C at the Golgi and the nucleus shown in magenta while the cellular cytoskeleton is shown in cyan (f-actin staining). Credit: Karolina Kuodyte/EMBL Our DNA is under constant threat. Chemicals, radiation and the everyday errors of cell division all damage it, and if left unrepaired, this can lead to diseases such as cancer. Cells invest heavily in finding and fixing these errors. A new study from EMBL Heidelberg's Pepperkok Group finds that part of the control over this repair process lies in an unexpected place—outside the nucleus, at the Golgi complex.
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