New molecule restores memory in animals with Alzheimer's' disease
Greek researchers have developed a new molecule, RSQ-020, that successfully restored memory in animal models with Alzheimer's disease. The team used a novel bacterial platform to identify molecules that repair misfolded proteins, offering a potential alternative to traditional drug discovery methods.
Why it matters
This represents a significant scientific breakthrough in neurodegenerative research, potentially changing how treatments for Alzheimer's are developed.
A Greek research team led by Giorgos Skretas has developed an innovative pharmaceutical molecule that, in preclinical tests, restored learning and memory capacity in animal models with characteristics of Alzheimer’s disease.The discovery is the result of collaboration between scientists at the Alexander Fleming Biomedical Sciences Research Centre, the National Hellenic Research Foundation and the spin-off company ResQ Biotech. The molecule, RSQ-020, acts by targeting the Tau protein which, when it folds abnormally and forms aggregates, is linked to the onset and progression of serious neurodegenerative disorders.The development of RSQ-020 relied on a new technological platform created by the same research group. The method uses modified bacteria which can produce an enormous number of different candidate molecules while simultaneously indicating which of them have genuine biological activity.
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