New insights into neuron-microglia interactions during brain aging
Researchers at the University of Tsukuba have discovered that aged neurons in mice release micronuclei, which are then absorbed by microglia. This interaction triggers inflammatory responses and changes in gene expression, providing new insights into brain aging.
Why it matters
Understanding the cellular mechanisms of brain aging is critical for developing future treatments for age-related neurodegenerative diseases.
edited by Lisa Lock , reviewed by Andrew Zinin
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Add as preferred source Model for the MN transfer from aged neurons to microglia. Age-related nuclear envelope fragility leads to the generation of MN, which are transferred to microglia and changes in the expression of HSPG-related genes. Credit: Frontiers in Aging Neuroscience (2026). DOI: 10.3389/fnagi.2026.1787252 Researchers at the University of Tsukuba have identified small nuclear fragments known as micronuclei while studying neurons in aged mice. They demonstrated that microglia—the brain's resident immune cells—take up these micronuclei, leading to changes in microglial morphology and gene expression associated with inflammation and vascular function. The research is published in the journal Frontiers in Aging Neuroscience .
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