New 'computational microscope' simulates DNA packaging at more than ten times previous scale
Researchers have developed a new computational tool called OpenCGChromatin that allows for high-scale simulations of DNA packaging. This 'computational microscope' helps scientists understand how chromatin folds and how molecular interactions influence genetic expression.
Why it matters
Advancements in molecular modeling provide critical insights into genetic diseases and the fundamental mechanics of cellular biology.
by Institute for Research in Biomedicine (IRB Barcelona)
edited by Gaby Clark , reviewed by Robert Egan
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
Add to Preferred Sources Coarse-grained nucleosome, showing histone core (blue), histone tails (cyan), and DNA (gray and white). Credit: IRB Barcelona The DNA in our cells wraps around proteins called histones to form nucleosomes, which organize into chromatin. This organization helps pack genetic material into the nucleus and influences how easily genes can be read and DNA damage repaired. Understanding how chromatin changes requires studying molecular movements and interactions that are difficult to capture experimentally.
Get smarter about the news
Sign up free for a feed built around what you actually care about, Dive Deeper research on any story, and the full text of every article.
Create free accountAlready have an account? Sign in