Mount Sinai researchers discover how Alzheimer's gene damages blood vessels
Researchers at Mount Sinai have discovered how the APOE4 gene, a primary genetic risk factor for Alzheimer's, damages brain blood vessels. The study, published in Cell and Cell Stem Cell, highlights how this gene promotes the accumulation of harmful proteins in the brain.
Why it matters
Understanding the specific mechanism by which APOE4 causes neurodegeneration provides a critical target for future drug development and Alzheimer's prevention strategies.
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