Most people may have a high genetic risk for diseases such as diabetes, heart disease and schizophrenia, study finds
A study from the University of Exeter suggests that the average person carries a high genetic risk for multiple common diseases, such as diabetes and heart disease. Researchers found that most individuals rank in the top 10% for genetic susceptibility to at least three out of 28 examined conditions.
Why it matters
Understanding polygenic risk scores helps clarify that genetic predisposition is common and does not serve as a definitive medical diagnosis.
Imagine looking at your DNA and finding that you rank among the 10% of people with the highest genetic risk for diabetes, heart disease or another common condition. You feel healthy, have no symptoms and may never develop the disease. Yet, your genetic profile could place you in a group considered more susceptible to it.That is the intriguing picture emerging from a new study led by researchers at the UK's University of Exeter. The team found that the average person may fall among the 10% at highest genetic risk for nearly three common conditions out of 28 examined, including diabetes, cardiovascular disease and schizophrenia.The surprising amount of variation in human DNAEvery person's genome contains approximately five million genetic variants, or DNA locations that differ between individuals, according to the study published in the journal Genome Medicine.Many of these differences have little or no known effect on health.
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