Phys.org·3 min read·hard

'Molecular sunscreen' may explain why DNA uses thymine despite its vulnerability to UV damage

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Amy Leifeste
'Molecular sunscreen' may explain why DNA uses thymine despite its vulnerability to UV damage
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Researchers at Texas A&M University are investigating why DNA uses thymine instead of uracil, despite thymine's higher vulnerability to UV radiation. The study uses biophotonics to simulate primordial Earth conditions to understand this evolutionary choice.

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Understanding the origins of molecular evolution provides insight into how life survived and persisted in the harsh conditions of early Earth.

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edited by Swati Mestri , reviewed by Robert Egan

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Add to Preferred Sources Schematic representation of the formation mechanisms of UV-induced CPD and (6-4) thymine photoproducts. Credit: Proceedings of the National Academy of Sciences (2026). DOI: 10.1073/pnas.2615278123 Scientists have long sought to understand the complex origins of intelligent life. It remains unclear how biological systems not only formed but survived and persisted under the extreme conditions of primordial Earth's hostile climate. Now, researchers at Texas A&M University are using light-based technologies to uncover new clues to help solve this evolutionary puzzle.

Dr. Peter Rentzepis, a professor in the Department of Electrical and Computer Engineering, and his research assistants Keyvan Khosh Abady and Negar Karpourazar have gained new insights into the origins of molecular evolution.

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