Molecular 'self-destruct' switch discovered: How stressed cells decide between survival and death

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Add as preferred source Proposed model illustrating chaperone-mediated and BAX/BAK-dependent pathways of ER protein redistribution. Credit: Dr. Aeid Ifbaria A new study from Ben-Gurion University of the Negev (BGU) has identified a molecular switch that controls whether stressed human cells activate a survival mechanism or trigger programmed cell death (apoptosis). The findings , published in Redox Biology , provide insights that could help overcome chemotherapy resistance in aggressive tumors.

The study was led by Dr. Aeid Igbaria alongside co-lead authors Laila Abu Madegam and Noa Gavriel and researcher Raifu Tolulope Adebisi, all from BGU's Department of Life Sciences.