Molecular GPS Guides Neutrophils to Sites of Infection

Researchers have identified a molecular mechanism that guides neutrophils to infection sites, involving the molecule hepoxilin A3 and the receptor TRPV2. This discovery explains how immune cells navigate the body and could lead to new treatments for chronic inflammatory diseases.
Why it matters
Understanding these cellular navigation signals provides a specific target for developing anti-inflammatory drugs that avoid damaging healthy tissue.
Data from a scientific collaboration between scientists at the University of Bath and UMass Chan Medical School helps explain how neutrophils, part of the immune system’s defense system, move through the body. Their findings shed light on the mechanisms that control neutrophil movement to specific infection sites without damaging healthy tissues along the way. According to the scientists, their findings point to a potential new target for anti-inflammatory drugs that can treat different conditions including chronic inflammatory diseases of the gut and lung.
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