Mechanistic development of a mild palladium-catalyzed C-S/C-H cross-coupling of thioesters with azoles
Researchers at KU Leuven have developed a mild, palladium-catalyzed method for the C-H acylation of azoles using stable thioester electrophiles. This new chemical process allows for more efficient cross-coupling reactions under less harsh conditions than previously available.
Why it matters
This advancement improves the efficiency and sustainability of chemical synthesis, which is critical for the development of complex pharmaceuticals and functional materials.
Communications Chemistry ( 2026 ) Cite this article
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