Mass-producible immune cells kill patient-derived colorectal tumors in mice

Kobe University researchers have developed a method to mass-produce immune cells derived from T cells that can effectively target and shrink colorectal tumors in mice. This breakthrough could lead to faster and more affordable cancer immunotherapies.
Why it matters
Current cancer immunotherapies are expensive and time-consuming; this 'off-the-shelf' approach could democratize access to life-saving treatments.
edited by Sadie Harley , reviewed by Robert Egan
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Add as preferred source Kobe University stem cell researcher AOI Takashi and his team report that they created iPS cells from a subclass of T cells that can be used across patients and could reproducibly turn them back into T cells with an overall 80,000-fold multiplication and without using animal cells or extracts, and that the resulting T cells attack and shrink human patient-derived colorectal cancer tumors that were implanted into mice. Credit: AOI Takashi Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted in mice. The Kobe University development is a significant contribution toward faster, cheaper cancer immunotherapy.
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