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Genetic Engineering and Biotechnology News·4 min read·hard

Macrophage Membrane-Derived Nanoparticles Shows Potential Against Candida Infections

U
Uduak Thomas
Macrophage Membrane-Derived Nanoparticles Shows Potential Against Candida Infections
AI Summary

Researchers have developed antifungal nanodiscs derived from human immune cell membranes to combat Candida infections. These particles are highly effective because they fuse with fungal membranes and boost the body's natural immune response.

Why it matters

This innovation offers a promising new strategy to treat drug-resistant fungal infections, which are a growing concern in global healthcare.

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By using tiny particles made from the membranes of human immune cells, scientists from the University of California, San Diego and the University of Missouri have created antifungal nanoparticles that target Candida albicans , a fungus responsible for oral and vaginal yeast infections as well as bloodstream infections. Tests in mice with severe Candida infections show that the macrophage-derived nanoparticles reduced the amount of fungus in major organs, including heart, kidneys, lungs, and spleen. The mice also had improved survival rates.

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