Lp(a) and the EAS Risk Calculator: Bringing Hidden Cardiovascular Risk into Clinical View-Dr Suraj Patil
Medical experts are emphasizing the importance of measuring Lipoprotein(a) [Lp(a)] as a genetically determined cardiovascular risk factor. New clinical guidelines and risk calculators are being implemented to help physicians better assess patient-specific heart disease risk.
Why it matters
Improves clinical diagnostic accuracy for cardiovascular disease by incorporating genetic markers that were previously overlooked.
Background: Lp(a) as an Independent, Genetically-Determined CV Risk Factor Cardiovascular risk assessment has conventionally relied on established factors — age, blood pressure, smoking status, diabetes, and standard lipid parameters. An important, largely inherited component of risk, however, can remain undetected by this framework: lipoprotein(a) [Lp(a)]. Predominantly genetically determined and generally stable across adulthood, elevated Lp(a) is independently associated with atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve stenosis. 1,3 Contemporary guidelines have progressively incorporated Lp(a) into cardiovascular risk assessment.
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